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| Tissue | Title | Type of Study | Gene Studied | abstract |
| blood, hematopoiesis | Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. | zebra | | abstract |
| Cancer | Gli and hedgehog in cancer: tumours, embryos and stem cells | Review | shh, gli1 | abstract |
| heart, muscle | Hedgehog signaling induces cardiomyogenesis in P19 cells. | cell | Meox1, Gli2, shh, MEF2C, Nkx2-5, GATA-4 | abstract |
| hematopoietic | Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. | cell line | | abstract |
| kidney | Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. | | shh | abstract |
| muscle | Muscle differentiation: a gene for slow muscle? | Review | Disp, Blimp1 | abstract |
| muscle | Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification | mouse | Gli | abstract |
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| muscle | Sonic hedgehog controls epaxial muscle determination through Myf5 activation. | mouse | shh | abstract |
| muscle | Sonic hedgehog is a survival factor for hypaxial muscles during mouse development | mouse | shh | abstract |
| muscle | Hedgehog can drive terminal differentiation of amniote slow skeletal muscle. | chick | shh, gli1 | abstract |
| muscle | Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors | zebra | smo | abstract |
| muscle, limb | Signals regulating muscle formation in the limb during embryonic development. | Review | | abstract |
| Neural | A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. | mouse | smo, Gli3 | abstract |
| Neural | Transplantation of oligodendrocyte precursors and sonic hedgehog results in improved function and white matter sparing in the spinal cords of adult rats after contusion | Rats | shh | abstract |
| Neural | A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. | Fly, Mice | ptch | abstract |
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| Neural | A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube | | | abstract |
| Neural | A role for p27/Kip1 in the control of cerebellar granule cell precursor proliferation. | C57BL/6 mice | p2,Kip1 | abstract |
| Neural | Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. | C57BL/6 X CBA F1 mice | shh, ptc, gli | abstract |
| Neural | Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. | Mice | Ptc1, shh, gli | abstract |
| Neural | From neural stem cells to myelinating oligodendrocytes. | Review | | abstract |
| Neural | Hedgehog signaling is required for the differentiation of ES cells into neurectoderm. | | smo | abstract |
| Neural | Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells | mouse | shh | abstract |
| Neural | Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells. | Sprague-Dawley Rats | ptch, smo, shh | abstract |
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| Neural | Sonic hedgehog and bone morphogenetic protein regulate interneuron development from dorsal telencephalic progenitors in vitro. | mice | shh | abstract |
| Neural | Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors | Swiss-Webster mice | G1 Cyclin, Cyclin D1, Cyclin D2, shh | abstract |
| Neural | Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. | mice | c-ret, Isl-1, En-1 | abstract |
| Neural | Specification of neuronal fates in the ventral neural tube. | Review | shh | abstract |
| Neural | The role of Sonic hedgehog in neural tube patterning. | Review | shh | abstract |
| Neural | The specification of neuronal identity by graded Sonic Hedgehog signalling. | Review | shh | abstract |
| Neural - cerebellar granule cells | Beta1-integrins are critical for cerebellar granule cell precursor proliferation | Mouse | p27, Kip1 | abstract |
| Neural - cerebellum, precursor | Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. | mouse | nmyc, ptch | abstract |
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| Neural - dopamine | Pleiotrophin mRNA is highly expressed in neural stem (progenitor) cells of mouse ventral mesencephalon and the product promotes production of dopaminergic neurons from embryonic stem cell-derived nestin-positive cells. | mouse | shh | abstract |
| Neural - dopaminergic (DA), serotonergic neurons | Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. | mouse | shh | abstract |
| Neural - dopaminergic neuron, GABA, astrocyte | Neural precursor cells derived from human embryonic brain retain regional specificity | human | shh | abstract |
| Neural - dopaminergic, Parkinson's | Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein | chick | shh | abstract |
| Neural - dopaminergic, parkinson's, gabaergic | Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. | mouse | shh | abstract |
| Neural - GABAergic neurons, oligodendrocytes | Differential modulation of BMP signaling promotes the elaboration of cerebral cortical GABAergic neurons or oligodendrocytes from a common sonic hedgehog-responsive ventral forebrain progenitor species. | Dlx1/2 mutant mice | shh | abstract |
| Neural - ganglion, retina | Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells | | | abstract |
| Neural - glial cells | Cerebellar granule cell precursors can differentiate into astroglial cells. | C57BL/6 mice | HNK-1 | abstract |
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| Neural - motor neuron, ventral interneuron | Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates. | mouse | shh | abstract |
| Neural - motor neurons | Directed differentiation of embryonic stem cells into motor neurons | Mouse | shh | abstract |
| Neural - motor neurons | Functional properties of motoneurons derived from mouse embryonic stem cells | mouse | shh | abstract |
| Neural - motor neurons and interneurons | A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. | chick | shh | abstract |
| Neural - neocortex | Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex. | Swiss-Webster mice | shh, gli2, gli3 | abstract |
| Neural - oligodendrocyte | Gli2 is required for normal Shh signaling and oligodendrocyte development in the spinal cord. | Mice | gli2 | abstract |
| Neural - oligodendrocyte | Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells. | cell culture | | abstract |
| Neural - oligodendrocyte | Oligodendrocytes can be generated from the local ventricular and subventricular zones of embryonic chicken midbrain. | chick | shh | abstract |
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| Neural - oligodendrocyte | Sonic hedgehog is a potent inducer of rat oligodendrocyte development from cortical precursors in vitro. | Sprague-Dawley Rats | shh | abstract |
| Neural - oligodendrocyte | Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. | rat | shh | abstract |
| Neural - oligodendrocyte | Transient expression of Olig1 initiates the differentiation of neural stem cells into oligodendrocyte progenitor cells | mouse | shh | abstract |
| Neural - oligodendrocytes | Induction of oligodendrocyte fate during the formation of the vertebrate neural tube. | Review | | abstract |
| Neural - oligodendrocytes, motor neurons | Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism. | chick | shh | abstract |
| Neural - oligodendrocytes, telencephalon | Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRalpha signaling. | mice | shh | abstract |
| Neural - peripheral neurons and floor plate cells | Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. | mouse, primate | shh | abstract |
| Neural - retinal ganglion | Hedgehogs and retinal ganglion cells: organizers of the mammalian retina. | review | | abstract |
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| Neural - schwann cells | Schwann cells as regulators of nerve development. | Review | | abstract |
| Neural - telencephalic | Directed differentiation of telencephalic precursors from embryonic stem cell | | | abstract |
| Neural - telencephalon, Oligodendrocyte | Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. | Wild-type rats (Sprague-Dawley) and mice (C57BL/6J) | Pdgfra, Shh and Ptc1 | abstract |
| Neural, gut | Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. | mouse | gli1, ptch1 | abstract |
| pancreas | Hedgehog signaling regulates expansion of pancreatic epithelial cells | mice | shh, ihh | abstract |
| pancreas, liver | A bipotential precursor population for pancreas and liver within the embryonic endoderm. | C3H mice | shh | abstract |
| signalling, mutations | Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division | | trol, hh, ttv | abstract |
| stem cell | Plasticity, niches, and the use of stem cells | Review | | abstract |
