Grants Pertaining to the Hedgehog Pathway

	Hedgehog Signaling Pathway Database
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Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
en	Amphioxus	Embryo		Conservation and Non-Conservation of Engrailed Gene Regulation in Metazoan Evolution: Amphioxus as a Model for the Ancestral Vertebrate	Holland, Linda	NSF-IOB	0236171	abstract
en	Amphioxus	Embro		Developmental Genetics of Amphioxus: Insights into the Origin and Evolution of the Vertebrate Body Plan	Holland, Nicholas	NSF-IOB	9630938	abstract
en	Annelids	Embryo		The Formation and Evolution of the Metameric Body Plan in Basal Annelids	Martindale, Mark	NSF-IOB	0094925	abstract
en	Annelids	Embryo		Dissertation Research: Involvement of Embryonic Developmental Processes in Regeneration and Asexual Reproduction: a Comparative Analysis in Annelids	Wray, Gregory	NSF-DEB	9623565	abstract
Shh	Astyanax mexicanus	Eye		Evolution of Eye Regression in Cavefish	Jeffery, William	NSF-IOB	0110275	abstract
en	Brachiopods	Embryo		The Developmental Basis for Evolutionary Changes in the Larval Biology of Brachiopods	Freeman, Gary	NSF-IOB	9982025	abstract
en	Butterfly	Embryo,wing		The Role of Developmental Genes in Controlling Butterfly Eyespot Patterns II	Monteiro, Antonia	NSF-IOB	0516705	abstract
en	Butterfly	Embryo, wing		The Role of Developmental Genes in Controlling Butterfly Eyespot Patterns	Monteiro, Antonia	NSF-IOB	0316283	abstract
hh	Butterfly	Embryo,wing		Pattern Formation and Eyespot Determination in Butterfly Wings	Carroll, Sean	NSF-IOB	9418449	abstract
gli	Danio rerio	Neuronal		SIGNALING CELL SPECIFICATION FOREBRAIN	KARLSTROM, ROLF	NIH-NINDS	5R01NS039994-04	abstract
iguana	Danio rerio	Embyro		Analysis of the role of the zebrafish iguana gene in hedgehog signalling	INGHAM,Philip	Wellcome Trust-UK	074974/Z/04/Z
shh	Danio rerio	Bone,epithelia		Craniofacial defects in ethanol-exposed zebrafish	AHLGREN, SARA	NIH-NIAAA	5R21AA013596-03	abstract
shh	Danio rerio	Neuronal		Specification of the Zebrafish Ventral Neural Tube	Halpern, Marnie	NSF-IOB	9604844	abstract
shh,twhh	Danio rerio	Neuronal		Specification of the Zebrafish Ventral Neural Tube	Halpern, Marnie	NSF-IOB	0080087	abstract
Shh	Danio rerio.Astyanax mexicanus	Teeth		Modularity in the Development and Evolution of the Dentition of Teleost Fishes	Stock, David	NSF-IOB	0092487	abstract
shh	Dano rerio	Neuronal, Muscle		Selecting for novel Hedgehog signaling mutations	DEVOTO, STEPHEN	NIH-NICHD	5R01HD044929-03	abstract
hh,ext1,ext2	Drosophila melangaster	embryo,imaginal disc		Mechanisms of Hedgehog Distribution and Signaling	THE, SIU	NIH-NIGMS	5R01GM066220-03	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
en	Drosophila melanogaster	Embryo		Genetics of Runt-dependent Transcriptional Regulation	Gergen, John	NSF-MCB	0344486	abstract
en	Drosophila melanogaster	Embryo		DNA Binding-Independent Transcriptional Regulation by Runt	Gergen, John	NSF-MCB	0090956	abstract
en	Drosophila melanogaster	Embryo		The Identification of Orthodenticle-interacting Genes in Drosophila	Finkelstein, Robert	NSF-IOB	9630394	abstract
en	Drosophila melanogaster	Embryo		Molecular Analysis of Developmental Mutations	O'Farrell, Patrick	NSF-IOB	9317299	abstract
en	Drosophila melanogaster	Embryo		Molecular Analysis of Developmental Mutations	O'Farrell, Patrick	NSF-IOB	9021142	abstract
en	Drosophila melanogaster	Embryo		Molecular and Genetic Characterization of the Drosophila Trans-acting Factor Elf-1	Bray, Sarah	NSF-MCB	8917480	abstract
en	Drosophila melanogaster	Embryo		Nuclear Migration and Early Zygotic Gene Action in Drosophila	Karr, Timothy	NSF-IOB	8802152	abstract
Hh	Drosophila melanogaster	embryo,imaginal disc		Mechanisms of Hedgehog Distribution and Signaling	THE, SIU		3R01GM066220-03S1
hh	Drosophila melanogaster	Embyro,Genital		Regulation of Hedgehog Signaling in the Drosophila Ovary	Montell, Denise	NSF-IOB	9983759	abstract
hh	Drosophila melanogaster	Embryo, eye		Pattern Formation in the Drosophila Eye Disc	Treisman, Jessica	NSF-IOB	9728140	abstract
hh, N	Drosophila melanogaster	Embryo		Signal Transduction Pathways in Drosophila Head Development	Finkelstein, Robert	NSF-IOB	9905684	abstract
hh,fu,cos2,ci.Sxl	Drosophila melanogaster	Embryo	cancer	Hedgehog Signaling and Sex-lethal Protein Localization	HORABIN, JAMILA	NIH-NIGMS	7R01GM061705-04	abstract
hh,pka	Drosophila melanogaster	Embryo		Hedgehog signaling in Drosophila	KALDERON, DANIEL	NIH-NIGMS	5R01GM041815-17	abstract
hh,pka,Slimb,rasp	Drosophila melanogaster	Embryo	cancer	REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA	JIANG, JIN	NIH-NIGMS	5R01GM061269-05	abstract
Hh,ptc,fu,ci,en	Drosophila melanogaster	Embryo		MOLECULAR MECHANISMS IN DEVELOPMENT	KORNBERG, THOMAS	NIH-NIGMS	5R01GM030637-23	abstract
hh,ptc,fu,cos2,ci	Drosophila melanogaster	cell line	cancer	RECONSTITUTION OF A HEDGEHOG SIGNALING COMPLEX	ROBBINS, DAVID	NIH-NCI	5R01CA082628-08	abstract
hh,ptc,smo,fu,cos2,ci	Drosophila melanogaster	Embryo		Regulation of Hh/Ci signaling by Cos2 and its partners	JIANG, JIN		5R01GM067045-03
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
ptc,disp	Drosophila melanogaster			Niemann Pick C disease in Drosophila	BHAT, KRISHNA		5R01NS045261-03
Smo,ci,hh	Drosophila melanogaster	embryo		Mechanism of Hedgehog signal transduction	HOOPER, JOAN	NIH-NIGMS	5R01GM069881-02	abstract
hh	Drosophila melanogaster,Triops longicaudatus	Embryo, Limb		Collaborative Research: Developmental Mechanisms Underlying Diversity in Arthropod Limbs	Williams, Terri	NSF-IOB	9904391	abstract
hh	Drosophila melanogaster,Triops longicaudatus	Embryo, Limb		Collaborative Research: Developmental Mechanisms Underlying Diversity in Arthropod Limbs	Nagy, Lisa	NSF-IOB	9874624	abstract
Shh,ptch1,smo	Gallus gallus	Neuronal,muscle,stem cells		Sonic Hedgehog Target Genes in Development and Cancer	EMERSON, CHARLES	NIH-NCI	5R01CA094089-04	abstract
shh	Gallus gallus,Mus musculus	Bone,epithelia		MORPHOGENESIS OF CRANIOFACIAL PRIMORDIA	HELMS, JILL	NIH-NIDCR	5R01DE012462-07	abstract
Shh,disp,ptch1, ptch2, gas1 and hip1	Gallus gallus,Mus musculus	Neuronal,Limb	cancer	Regulation of CNS and Limb Polarity by Sonic Hedgehog	MCMAHON, ANDREW	NIH-NINDS	2R37NS033642-11	abstract
hh	Helobdella robusta	Embryo		Cellular and Molecular Events in Early Leech Development	Weisblat, David	NSF-IOB	0091261	abstract
en	Helobdella triserialis	Embryo		RPG: Molecular & Cellular Interphyletic Homology of Segmentation	Wedeen, Cathy	NSF-IOB	9509099	abstract
ptc	Homo sapiens	epithelia	cancer	BASAL CELL CARCINOMA CHEMOPREVENTION IN BCNS PATIENTS	EPSTEIN, ERVIN	NIH-NCI	5U19CA081888-05	abstract
ptc	Homo sapiens	Mammary	cancer	Novel Gene Networks in Breast Development and Cancer	OSBORNE, C	NIH-NCI	5P01CA030195-23	abstract
shh	Homo sapiens	Prostate, Genital		Hedgehog Pathway in Urogenital Sinus Development	BERMAN, DAVID	NIH-NIDDK	5K08DK059375-05	abstract
shh, ihh, ptch, smo, Gli1, hip,Bmi-1	Homo sapiens	Liver	cancer	Hedgehog signaling in human hepatocellular carcinoma	CHEN, XIN	NIH-NCI	1R21CA113393-01	abstract
shh	Homo sapiens, Mus musculus	stem cells	cancer	Hedgehog signaling in tissue injury and carcinogenesis	BEACHY, PHILIP	NIH-NCI	1R01CA116586-01	abstract
shh	Homo sapiens, Mus musculus	Prostate	cancer	Sonic Hedgehog Induces Prostate Development	BUSHMAN, WADE	NIH-NIDDK	5R01DK052687-08	abstract
dhh,ihh	Homo sapiens, Rattus norvegicus	Pancreas,stem cells	cancer,diabetes	Program Project,Restoration of Endocrine Pancreas Funct*	HABENER, JOEL	NIH-NIDDK	5U19DK061251-03	abstract
dhh,ihh,shh	Mus musculus	Pancreas	cancer,diabetes	Embryonic Signaling Pathways in Pancreatic Cancer	HEBROK, MATTHIAS	NIH-NCI	5R01CA112537-02	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
Gli2,gli3,shh	Mus musculus	Neuronal, Limb,epithelia		Roles of Mouse Gli Genes in Hedgehog Signaling	JOYNER, ALEXANDRA	NIH-NICHD	5R01HD035768-09	abstract
hh,shh,ptc,smo	Mus musculus	Neuronal Limb		MOLECULAR MECHANISMS OF HEDGEHOG RECEPTOR FUNCTION	BEACHY, PHILIP	NIH-NICHD	5R01HD039306-05	abstract
ihh	Mus musculus	bone	osteoporosis	Indian Hedgehog Signaling in Osteoblast Differentiation	LONG, FANXIN	NIH-NIDDK	5R01DK065789-02	abstract
ihh	Mus musculus	Genital		Molecular Analysis of Uterine Receptivity	DEMAYO, FRANCESCO	NIH-NICHD	5U01HD042311-04	abstract
ihh	Mus musculus	Endoderm,mesoderm		Indian Hedgehog and Early Mouse Embryogenesis	Grabel, Laura	NSF-IOB	9604367	abstract
ihh,dhh,hip	Mus musculus	pancreas		Effects of Hedgehog Signaling on Pancreas Organogenesis	HEBROK, MATTHIAS	NIH-NIDDK	5R01DK060533-03	abstract
Pka,ptch1	Mus musculus	neuronal,brain	cancer	PKA modulation of hedgehog: mouse medulloblastoma model	WASCHEK, JAMES	NIH-NCI	1R01CA110384-01A1	abstract
ptc	Mus musculus	Epithelia	cancer	Basal Cell Carcinoma:Molecular Pathogenesis & Prevention	BICKERS, DAVID	NIH-NCI	5R01CA097249-04	abstract
ptc,smo,hip,shh	Mus musculus	Embryo		Hedgehog signal modulation in mammalian development	CHUANG, PAO-TIEN	NIH-NHLBI	5R01HL067822-05	abstract
Ptc1,Shh	Mus musculus	mammary	cancer	PTC1 Hedgehog Receptor in Mammary Development /Neoplasia	LEWIS, MICHAEL	NIH-NCI	5P01CA030195-230024	abstract
Ptch1,smo,Gli1,Gli2,Gli3, GH2	Mus musculus	epithelia	cancer	Molecular Basis of Epithelial Skin Cancer	DLUGOSZ, ANDRZEJ	NIH-NCI	2R01CA087837-05A1	abstract
shh	Mus musculus			Hedgehog signaling and intracellular transport	EGGENSCHWILER, JONATHAN	NIH-NICHD	1R01HD050761-01	abstract
shh	Mus musculus	Epithelia,endoderm		Epithelial-mesenchymal interactions in gut morphogenesis	RUBIN, DEBORAH	NIH-NIDDK	5R01DK061216-06	abstract
shh	Mus musculus	Limb		Hedgehog signaling and organogenesis of the limb	TABIN, CLIFFORD	NIH-NICHD	2R37HD032443-11	abstract
shh	Mus musculus	ECM		Proteoglycans Modulate Sonic Hedgehog Responses	CHAN, JENNIFER	NIH-NICHD	1K08HD048595-01	abstract
shh	Mus musculus	Neuronal	Neurodegeneration	Genetic Analysis of Neurodegeneration	ACKERMAN, SUSAN	NIH_NIA	5R01AG019358-04	abstract
shh	Mus musculus	Neuronal		Specification of Cortical Interneurons	ANDERSON, STEWART	NIH-NIMH	5K02MH070031-02	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
shh	Mus musculus	Hair		Molecular Regualtion of Hair Follicle Morphogenesis	DLUGOSZ, ANDRZEJ	NIH-NIAMS	2R01AR045973-06	abstract
shh	Mus musculus	Neuronal		Transcriptional control of sonic hedgehog signaling	EPSTEIN, DOUGLAS	NIH-NINDS	2R01NS039421-06	abstract
shh	Mus musculus	Bone	Chondrodysplasia	Molecular Studies of X-Linked Chondrodysplasia Punctata	HERMAN, GAIL	NIH-NICHD	2R01HD038572-14	abstract
Shh	Mus musculus	pharyngeal		Role of Sonic hedgehog in pharyngeal organ development	MANLEY, NANCY	NIH-NICHD	5R03HD043479-02	abstract
Shh,Beg4	Mus musculus	Epithelia	cancer	Genetic Analysis of the Sonic Hedgehog Target Gene BEG4	CALLAHAN, CHRISTOPHER	NIH-NIAMS	5K08AR047803-05	abstract
shh,FoxM1	Mus musculus	neuronal		Mechanisms of hedge-hog induced neuroproliferation	ROWITCH, DAVID	NIH-NINDS	5R01NS047527-02	abstract
shh,gli	Mus musculus	Neuronal		Molecular Control of Shh/Gli Signalling in the Vertebrate CNS	Matise, Michael	NSF-IOB	0131264	abstract
shh,Gli2,Gli3,Pax6	Mus musculus	Neuronal, brain		Sonic Hedgehog Signaling in the Mammalian Telencephalon	FISHELL, GORDON	NIH-NINDS	5R01NS039007-06	abstract
shh,ptc	Mus musculus	Pancreas	cancer	Hedgehog signaling in pancreatic neoplasia	MAITRA, ANIRBAN	NIH-NIDDK	1R21DK072532-01	abstract
Shh,ptc,gli	Mus musculus	Neuronal, brain	cancer	Hedgehog, Patched, and Gli in Medulloblastoma	WEINER, HOWARD	NIH-NCI	5K08CA093450-04	abstract
shh,rab23	Mus musculus	Neuronal		Genetic Analysis of Mouse Nervous System Development	ANDERSON, KATHRYN	NIH-NINDS	5R01NS044385-04	abstract
shh,smo	Mus musculus	Ear		Regulating dorsoventral polarity within the inner ear	EPSTEIN, DOUGLAS	NIH-NIDCD	5R01DC006254-03	abstract
smo,gli1	Mus musculus	epithelia	cancer	Molecular Basis of Hedgehog Signaling in Carcinogenesis	XIE, JINGWU	NIH_NCI	5R01CA094160-04	abstract
smo,Hes5,notch2	Mus musculus	Neuronal,brain	cancer	bHLH Factors in Medulloblastoma Genesis and Maintenance	OLSON, JAMES	NIH-NCI	1R01CA112350-01A1	abstract
sufu	Mus musculus	epithelia	cancer	Suppressor of fused gene in Carcinogenesis	BALE, ALLEN	NIH_NCI	5R01CA093908-02	abstract
ptch,smoh	Mus musculus,Homo sapiens	Embyro		Regulation of Hedgehog Receptor Trafficking and Function	KARPEN, HEIDI	NIH-NICHD	5K08HD042078-04	abstract
shh	Mus musculus,Homo sapiens	Pancreas	cancer	The Hedgehog Pathway and Pancreatic Neoplasia	THAYER, SARAH	NIH-NIDDK	5K08DK071329-02	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
shh	Mus musculus,Homo sapiens	Pancreas	cancer	Hedgehog Inhibitors in Pancreas Cancer	MAITRA, ANIRBAN	NIH-NCI	1R01CA113669-01	abstract
shh,ptc,smo,gli	Mus musculus,Rattus norvegicus	Angiogenesis,heart		Progenitor Cells in Vascular Biology	LOSORDO, DOUGLAS	NIH-NHLBI	2R01HL057516-09	abstract
hh	Schistocerca americana	Eye		Functional Analysis of Eye Development in the Grasshopper	Friedrich, Markus	NSF-IOB	0091926	abstract
shh	Xenopus lavis, Gallus gallus	Angiogenesis,Heart		Embryonic Blood Vessel Formation	KRIEG, PAUL	NIH-NHLB	5R01HL074184-03	abstract
en				Structure and Selectivity of Designed Metallohomeodomains	Franklin, Sonya	NSF-MCB	0451199	abstract
en				MRI: Procurement of a Shared Confocal Microscope Facility at the Institute of Neurobiology	Miller, Mark	NSF-DBI	0115825	abstract
en				Molecular Analysis of Developmental Mutations	O'Farrell, Patrick	NSF-IOB	8719293	abstract
Gli				Function of the Gli Genes in Sonic Hedgehog Signaling	RUIZ I ALTABA, ARIEL		5R01NS037352-08
Gli			cancer	Role of GLI in Tumor progression	RUPPERT, J	NIH-NCI	5R01CA094030-04
Gli				ENVIRONMENT & GLI GENES IN NORMAL DEVELOPMENT & DISEASE	IANNACCONE, PHILIP		5P01ES010549-05
Gli		Mammary	cancer	Gli Control of PTH-rP and Osteolysis in Breast Cancer	MUNDY, GREGORY	NIH-NCI	1R01CA114000-01
Gli				COMPARATIVE GENETICS OF GLI FUNCTION	SCHIER, ALEXANDER		7R01DE016779-02
Gli		Epithelia	cancer	Role of Glil in Basal Cell Carcinoma Development	Ruiz I Altaba, Ariel	NCI	CA078736	abstract
Gli2				The molecular regulation of Gli2 in Hedgehog signaling	WANG, BAOLIN		5R01GM070820-02
gli2		Bone		Regulation of PTHrP expression in chondrocytes by Gli2	STERLING, JULIE		5F32AR051639-02
Gli3				Mechanism of Gli3 processing in Hedgehog signaling	WANG, BAOLIN	NIH-NCI	5R01CA111673-02
hh,shh,ihh,ehh,dhh,twhh				RUI: Acquisition of Protein Purification and Analysis Instrumentation to Enhance Biochemical Research and Education at the College of the Holy Cross	Mills, Kenneth	NSF-DBI	0320824	abstract
Gene	Organism	Tissue	Disease	Project Title	PI Name	Funding Agency	Grant Number	Abstract
hh,shh,ptc,ptc		Embryo		U.S.-France Cooperative Research: Molecular Dissection of the Hedgehog/patched Signal Transduction Pathway	Scott, Matthew	NSF-OISE	9603417	abstract
Ift 88				Analysis of Flexo/lft88, a novel regulator of Hh pathway	LIU, AIMIN		5F32HD045090-03
ptch		Thyroid		THYROID-SPECIFIC RET/PTC ONCOGENE	JHIANG, SISSY	NIH-NCI	5R01CA060074-10
shh		stem cells	cancer	Developmental pathways, cancer, and DNA hypermethylation	BAYLIN, STEPHEN	NIH-NCI	1R01CA116160-01	abstract
Shh				Characterization of a soluble form of Sonic Hedgehog	ROBBINS, DAVID		5R01GM064011-05
Shh			cancer	Teratogens as probes of Sonic hedgehog signaling	COOPER, MICHAEL		5K08NS002133-05
Shh				Can abnormal Shh signaling cause ED?	PODLASEK, CAROL		1R01DK068507-01A1
Shh		Neuronal		Factors Influencing Shh Signaling in the Forebrain	KOHTZ, JHUMKU		5R01HD044745-03
shh		Prostate	cancer	Shh Signaling as a Therapeutic Target in Prostate Cancer	Bushman, Wade A.	NCI	CA095386	abstract
Shh,ptc				Receptor Trafficking and the Response to Shh	ROELINK, HENK		1R01GM072207-01A2
shh,smo,ptc			cancer	Genome-Based Targeting of the Hedgehog Pathway in Cancer	Beachy, Philip A	NCI	CA095957	abstract
sister of open brain				Characterization and Cloning of Sister of Open Brain	QIN, JIAN		5F32NS050480-02
smo				Determinants of Smoothened Activity	WILLIAMS, ELIZABETH		5F32GM071168-02
smo				Determinants of Smoothened Activity	WILLIAMS, ELIZABETH		abstract


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